Skinboosters vs. Rejuran: An aesthetic doctor reviews

Trends come and go, but the obsession with looking young is forever. In aesthetics, skinboosters and Rejuran are two highly sought-after treatments in the centre of this anti-ageing craze. Not only do they promise to rejuvenate the skin and reverse signs of ageing, but they are also administered in the same manner too. Thus, it’s easy to get confused between the two.

In this article, I will compare Skinboosters and Rejuran and you’ll see that while both tackle skin ageing, they differ greatly in their approach.

Introduction to Skinboosters

Skinboosters are filler treatments that work on hydrating the skin from within. They contain hyaluronic acid, a natural component of our skin that has the ability to draw water up to 1000 times its own weight. In fact, hyaluronic acid is a common ingredient used in moisturisers and serums due to their hydrating abilities. As we all know, hydration is crucial for healthy and youthful-looking skin. Without adequate skin hydration, we get dehydrated skin, which is flaky, wrinkly and can make us look old.

How does it work?

By plumping hyaluronic acid into our skin, we increase the amount of moisture we get, resulting in radiant and healthier-looking skin. Besides hydration, hyaluronic acid also carries wound healing properties and is thus fantastic on shallow acne scars. On top of that, Skinboosters have been found to stimulate the formulation of elastin fibres and collagen. By replacing lost collagen and elastin fibres from ageing, we now get skin that’s a lot firmer and thicker.

Benefits of Skinboosters

  • Increase in skin hydration
  • Increase in skin smoothness and elasticity
  • Increase in skin brightness
  • Reduced fine lines and wrinkles
  • Improvement of pores and acne scars

How are Skinboosters administered?

Skinboosters are administered through a series of microinjections either by hand or via an injector machine. When hyaluronic acid from skinboosters is injected into the skin, it draws water into the dermis and keeps the dermis hydrated. Due to this action, the skin is healthier and younger.

Introduction to Rejuran

Rejuran is an anti-ageing treatment that works on the principle of increasing DNA synthesis. Its main ingredient, Polynucleotide (PN), is a fragment of DNA that has been used in medical treatments for healing damaged skin, skin ulcers and treating hair loss.

The polynucleotides in Rejuran are extracted from salmon DNA, which first undergoes a rigorous and sterile purification process to remove any substances that can trigger immune responses in the body. They are then broken up into polydeoxyribonucleotides (PDRN), which are key in Rejuran’s anti-ageing effect.

How does it work?

When introduced to the skin, PDRN brings about a few effects:

  1. Increase vascular endothelial growth factor, which is a substance that stimulates the formation of new blood vessels. Blood vessels aid in wound healing and skin repair.
  2. Reduce inflammation in the body by increasing our body’s natural antioxidant reserves. We generally want to avoid inflammation as inflammation generates free radicals that damage our cell DNA, collagen, proteins and cell membrane.
  3. Increase fibroblasts, which stimulate collagen production in our skin. Collagen plays a major role in fighting ageing.
  4. Generate nucleotides which form new DNA. This new DNA stimulates cell growth and leads to faster tissue regeneration.

Benefits of Rejuran

  • Increase in skin elasticity and hydration
  • Reduced fine lines and wrinkles
  • Reduced acne scars and skin pigmentation
  • Reduced skin surface roughness
  • Improved skin tone

How is Rejuran administered?

Like Skinboosters, Rejuran is also administered through a series of microinjections either by hand or an injector gun.

Rejuran vs Skinboosters

Main ingredientHyaluronic acidPolynucleotides from salmon DNA
Working mechanismWorks through deep skin hydration and collagen productionWorks by stimulating DNA synthesis, bringing down inflammatory levels and increasing collagen levels
BenefitsReverse signs of ageing, hydrated skin, brighter and radiant skin, reduced acne scarsReverse signs of ageing, reduced inflammation, brighter and more radiant skin, reduced acne scars
Best suited forPatients with dehydrated skin, signs of ageing, depressed acne scars and large pores, dull skinPatients with signs of ageing, depressed acne scars and large pores, dull skin
Treatment regime3 treatments done 4 weeks apart, thereafter maintenance every 6 to 12 months3 treatments done 2-4 weeks apart, thereafter maintenance every 6 to 12 months

Which is for me?

As skin boosters work primarily on hydrating the skin, it is recommended for individuals who are facing ageing skin due to dry skin and want to reduce fine lines and wrinkles.

Rejuran, on the other hand, is focused on skin regeneration and repair. Hence, it might be better for older individuals with severely damaged and aged skin that mere hydration cannot fix. Individuals with acne scarring may benefit better from Rejuran as well. Rejuran’s skin repair and anti-inflammatory properties can improve skin healing, smoothen out skin and reduce the appearance of acne scars.

Do you have any questions for me?

I am more than happy to answer them at contact@mymedicalaesthetics.com and (65) 6873 8238


  1. Nikolis, A., & Enright, K. M. (2018). Evaluating the role of small particle hyaluronic acid fillers using micro-droplet technique in the face, neck and hands: a retrospective chart review. Clinical, cosmetic and investigational dermatology11, 467–475. https://doi.org/10.2147/CCID.S175408
  2. Jeong, W., Yang, C. E., Roh, T. S., Kim, J. H., Lee, J. H., & Lee, W. J. (2017). Scar Prevention and Enhanced Wound Healing Induced by Polydeoxyribonucleotide in a Rat Incisional Wound-Healing Model. International journal of molecular sciences18(8), 1698. https://doi.org/10.3390/ijms18081698
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